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Current and Emerging Data on SGLT2 Inhibitors in Heart Failure

Topic:
  • CV Renal Metabolic
  • Heart Failure
  • Prevention

Available Credit:

  • 1.00 EBAC

Course Published On:

Course Expiry Date:

Current and Emerging Data on SGLT2 Inhibitors in Heart Failure

Overview

The opportunity for cardiovascular disease prevention in patients with type 2 diabetes mellitus (T2DM) has recently expanded with antihyperglycemic agents demonstrating significant reductions in the risk of major adverse cardiovascular events (MACE) including sodium-glucose co-transporter-2 (SGLT2) demonstrating robust reductions in heart failure (HF). Although the exact mechanisms of cardiovascular (CV) benefit remain uncertain, they appear to be unrelated to the direct glucose-lowering effects.

 

Recent trials — including the recently presented DAPA-HF — have provided further insight into the effectiveness of SGLT2 inhibitors in patients with heart failure with reduced ejection fraction (HFrEF) and heart failure with preserved ejection fraction (HFpEF) in the absence of T2DM.

Support Statement

This activity has been supported by an unrestricted educational grant from AstraZeneca.

Disclosure

In compliance with EBAC / EACCME guidelines, all speakers/chairpersons participating in this programme have disclosed or indicated potential conflicts of interest which might cause a bias in the presentations. 

 

The Organising Committee/Course Director is responsible for ensuring that all potential conflicts of interest relevant to the event are declared to the audience prior to the CME activities.

Terms & Conditions

Radcliffe Education requires contributors to our CME programmes to disclose any relevant financial relationships that have occurred within the past 12 months that could create a conflict of interest. These will be identified in the faculty section if applicable.

Instruction to Participants

There is no fee for taking part in this online learning activity.

 

Activities are designed to be completed within 60 minutes and must be completed by the registered user. Physicians should only claim credits for time spent on the activity. To successfully earn credit, participants must complete the activity in full in the indicated time frame.

 

To complete the course and claim certification participants must:

 

1. Read the course outline information supplied and complete pre-test questions if supplied prior to starting the activity. Users must read and study the activity in its entirety before completing the post-test questions.

 

2. Your results will be automatically saved and if a pass score is achieved (where applicable), you may be eligible to claim credit for the activity and receive a certificate of completion.

Target Audience

  • Heart Failure Specialists
  • General Cardiologists

Learning Objectives

Upon completion of this activity, participants will be able to:

  • Understand the SGLT2 inhibitor cardiovascular outcome trial (CVOT) data;
  • differentiate the latest guideline updates for the treatment of T2D and their recommendations regarding the importance of considering comorbidities, including atherosclerotic cardiovascular disease (ASCVD) and heart failure (HF);
  • apply clinical and real-world evidence of the SGLT2 inhibitor class for use in prevention of hospitalisation in HF, as well as future ongoing studies in the treatment of HF;
  • assess the interrelationships linking diabetes, HF and CVD;
  • interpret the potential cardio-renal mechanisms of the SGLT2 inhibitor class in reducing the risk of CV, including HF. Evaluate emerging data of the treatment of HF with SGLT2 inhibitors in patients with or without T2DM.
1.

Welcome and Introduction

Duration:

Speakers: Felipe Martínez (Universidad Nacional de Córdoba, Córdoba, AR)

3.

DAPA-HF – Clinical Trial Design Rationale

Duration:

Speakers: Felipe Martínez (Universidad Nacional de Córdoba, Córdoba, AR)

4.

SGLT2i Beyond Diabetes – Mechanism of Benefit in CVD

Duration:

Speakers: Lars H Lund (Karolinska Institutet, Stockholm, SE)

6.

The Dapagliflozin and Prevention of Adverse Outcomes in HF trial

Duration:

Speakers: Frank Ruschitzka (University hospital Zurich, Zurich, CH)

8.

Course Director

Felipe Martínez

National University of Cordoba, Cordoba, AR

Emeritus Professor of Medicine - Cordoba National University
Director - Instituto DAMIC-Fundación Rusculleda, Córdoba, Argentina
Fellow of the European Society of Cardiology (FESC)
Fellow of the American College of Cardiology (FACC)

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Speaker

Scott Solomon

Brigham and Women's Hospital, Boston, US / Harvard Medical School

Prof Scott D Solomon is the Edward D Frohlich Distinguished Chair at Harvard Medical School, Director of Noninvasive Cardiology and Senior Physician at Brigham and Women’s Hospital.

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Andrew JS Coats

Heart Research Institute, NSW, AU

Prof Coats is Editor-in-Chief of the Cardiac Failure Review journal. He has published over 20 patents, more than 750 full research papers and more than 120,000 career citations and has a personal H-index of

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Carolyn Lam

National Heart Centre Singapore Duke-NUS, Singapore

Prof Carolyn Lam is a Senior Consultant at the Department of Cardiology and Director of Women's Heart Health at the National Heart Centre Singapore, having pioneered the first Women’s Heart Clinic in Singapore.

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Lars H Lund

Karolinska Institute and Karolinska University Hospital, Stockholm, SE

Dr Lund's expertise is in HF big data and registry-based comparative outcomes studies and pragmatic trials. He is active in programs to improve utilisation of existing evidence-based interventions in heart failure with reduced ejection fraction, as well as in novel interventions.

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Frank Ruschitzka

University Heart Centre, University Hospital ZurichZurich, Switzerland

Professor Frank Ruschitzka, MD, FRCP (Edinburgh), FESC received his medical degree from the University of Gottingen in Germany in 1989. He specialized in internal medicine, nephrology and cardiology at the Universities of Gottingen and Zurich. 

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John JV McMurray

Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, UK

Prof John McMurray is Professor of Medical Cardiology and Deputy Director of the Institute of Cardiovascular and Medical Sciences at the University of Glasgow, and honorary Consultant Cardiologist at the Queen Elizabeth University Hospital, Glasgow.

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Mikhail Kosiborod

Saint Luke’s Mid America Heart Institute, Kansas City, US

Dr Mikhail Kosiborod is a cardiologist, the Vice President of Research at Saint Luke's Health System, and Professor of Medicine at the University of Missouri-Kansas City, US.

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1.00 EBAC

The event ‘Current and Emerging Data on SGLT2 Inhibitors in Heart Failure’ is accredited by the European Board for Accreditation in Cardiology (EBAC) for 1 hour of external CME credits.

 

Each participant should claim only those hours of credit that have actually been spent in the educational activity. EBAC works according to the quality standards of the European Accreditation Council for Continuing Medical Education (EACCME), which is an institution of the European Union of Medical Specialists (UEMS).

 

Through an agreement between the European Board for Accreditation in Cardiology and the American Medical Association, physicians may convert EBAC External CME credits to AMA PRA Category 1 Credits™. Information on the process to convert EBAC credit to AMA credit can be found on the AMA website.

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